Vitamin K-dependent clotting factor (specifically, Factor II [Prothrombin], Factor VII [often used as activated FVIIa], Factor IX, Factor X) (None)

Vitamin K–dependent clotting factors (prothrombin [FII], factor VII, factor IX, factor X) are serine proteases essential for the propagation of the coagulation cascade. Their activity depends on post-translational gamma-carboxylation, a process that requires vitamin K, allowing these proteins to bind membranes and calcium, enabling proteolytic activation steps in clot formation. Therapeutic provision of these factors, via plasma-derived concentrates or recombinant proteins, is a mainstay for correcting deficiencies due to inherited or acquired disorders, or for reversal of vitamin K antagonist therapy[1][2][4][5].

Other names

Vitamin K–dependent coagulation factorsVK-dependent clotting factorsprothrombin complex factorsvitamin K–dependent serine proteases

Replacement or supplementation of deficient clotting factor(s) to restore hemostasis Promotion of coagulation cascade via enzymatic cleavage of pro-enzymes to active forms (serine protease activity)